Abstract:
The RTS,S/AS02A malaria vaccine is based on the Plasmodium
falciparum circumsporozoite protein (PfCSP), which is O-
fucosylated on the sporozoite surface. We determined whether
RTS,S/AS02A-induced immunoglobulin G (IgG) antibodies
recognize vaccine-like nonfucosylated PfCSP better than native-
like fucosylated PfCSP. Similar to previous vaccine trials, RTS,S/
AS02A vaccination induced high anti-PfCSP IgG levels
associated with malaria protection. IgG recognition of
nonfucosylated and fucosylated PfCSP was equivalent, suggesting
that PfCSP fucosylation does not affect antibody recognition.
