First-line antituberculosis drug concentrations in infants with HIV and a history of recent admission with severe pneumonia

Chabala, Chishala; Jacobs, Tom G.; Moraleda, Cinta; Ndaferankhande, John M.; Mumbiro, Vivian; Passanduca, Alfeu; Namuziya, Natasha; Nalwanga, Damalie; Musiime, Victor; Ballesteros, Alvaro; Domínguez-Rodríguez, Sara; Chitsamatanga, Moses; Cassia, Uneisse; Nduna, Bwendo; Bramugy, Justina; Sacarlal, Jahit; Madrid, Lola; Nathoo, Kusum J.; Colbers, Angela; Burger, David M.; Mulenga, Veronica; Buck, W. Chris; Mujuru, Hilda A.; Brake, Lindsey H. M. te; Rojo, Pablo; Tagarro, Alfredo; Aarnoutse, Rob E.

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First-line antituberculosis drug concentrations in infants with HIV and a history of recent admission with severe pneumonia

Chabala, Chishala; Jacobs, Tom G.; Moraleda, Cinta; Ndaferankhande, John M.; Mumbiro, Vivian; Passanduca, Alfeu; Namuziya, Natasha; Nalwanga, Damalie; Musiime, Victor; Ballesteros, Alvaro; Domínguez-Rodríguez, Sara; Chitsamatanga, Moses; Cassia, Uneisse; Nduna, Bwendo; Bramugy, Justina; Sacarlal, Jahit; Madrid, Lola; Nathoo, Kusum J.; Colbers, Angela; Burger, David M.; Mulenga, Veronica; Buck, W. Chris; Mujuru, Hilda A.; Brake, Lindsey H. M. te; Rojo, Pablo; Tagarro, Alfredo; Aarnoutse, Rob E.

URI: http://www.repositorio.uem.mz/handle258/959

Date: 2023

Abstract:

Optimal antituberculosis therapy is essential for favorable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared with refer- ence values for adults, supporting studies on increased doses of first-line TB drugs in infants.

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