Faculdade de Medicina - FAMED: Recent submissions

  • Long-term follow-up of human immunodeficiency virus-associated pulmonary hypertension: clinical features and survival outcomes of the Pan Africa Pulmonary Hypertension Cohort (PAPUCO) 
    Thienemann, Friedrich; Katoto, Patrick D. M. C.; Aziban, Feriel; Kodogo, Vitaris; Mukasa, Sandra L.; Sani, Mahmoud U.; Karaye, Kamilu M.; Mbanze, Irina; Mocumbi, Ana O.; Dzudie, Anastase; Sliwa, Karen (Oxford University Press, 2022)
    Data characterizing risk factors and long-term outcome studies on human immunodeficiency virus (HIV)-associated pulmonary hypertension (PH) in Africa are lacking.The Pan African Pulmonary Hypertension Cohort, a multinational ...
  • Research priorities for the secondary prevention and management of acute rheumatic fever and rheumatic heart disease: a National Heart, Lung, and Blood Institute workshop report 
    Karthikeyan, Ganesan; Watkins, David; Bukhman, Gene; Cunningham, Madeleine W.; Haller, John; Masterson, Mary; Mensah, George A.; Mocumbi, Ana O.; Muhamed, Babu; Okello, Emmy; Sotoodehnia, Nona; Machipisa, Tafadzwa; Ralph, Anna; Wyber, Rosemary; Beaton, Andrea (BMJ Global Health, 2023-05)
    Secondary prevention of acute rheumatic fever (ARF) and rheumatic heart disease (RHD) involves continuous antimicrobial prophylaxis among affected individuals and is recognised as a cornerstone of public health programmes ...
  • Rheumatic heart disease in Africa: is there a role for genetic studies? 
    Mocumbi, Ana O. (Cardiovascular Journal of Africa, 2015)
    Rheumatic heart disease (RHD) constitutes a leading cause of premature death and incapacity in Africa, where it is encountered in younger people, and shows a much faster and more malignant course than that seen in Europe ...
  • Winter peaks in heart failure: an inevitable or preventable consequence of seasonal vulnerability? 
    Stewart, Simon; Moholdt, Trine T.; Burrell, Louise M.; Sliwa, Karen; Mocumbi, Ana O.; McMurray, John J.V.; Keates, Ashley K.; Hawley, John A. (Radcliffe Cardiology, 2019)
    Climate change is a major contributor to annual winter peaks in cardiovascular events across the globe. However, given the paradoxical observation that cardiovascular seasonality is observed in relatively mild as well as ...
  • Tertiary prevention and treatment of rheumatic heart disease: a national heart, lung, and blood institute working group summary 
    Vervoort, Dominique; Yilgwan, Christopher Sabo; Ansong, Annette; Baumgartner, Jennifer N.; Bansal, Geetha; Bukhman, Gene; Cannon, Jeffrey W.; Cardarelli, Marcelo; Cunningham, Madeleine W.; Fenton, Kathleen; Green-­Parker, Melissa; Karthikeyan, Ganesan; Masterson, Mary; Maswime, Salome; Mensah, George A.; Mocumbi, Ana O.; Kpodonu, Jacques; Okello, Emmy; Remenyi, B.; Williams, Makeda; Zühlke, Liesl J.; Sable, Craig (BMJ, 2023-05)
    Although entirely preventable, rheumatic heart disease (RHD), a disease of poverty and social disadvantage resulting in high morbidity and mortality, remains an ever-­present burden in low-­income and middle-­income countries ...
  • Neglected tropical cardiomyopathies, Chagas disease: Myocardial disease 
    Yacoub, Sophie; Mocumbi, Ana O.; Yacoub, Magdi H. (BMJ, 2008)
    Cardiomyopathies, defined as diseases of the myo- cardium associated with cardiac dysfunction, are classified into dilated, hypertrophic, restrictive and arrhythmogenic right ventricular cardiomyopathy, as well as ...
  • Systems analysis and improvement approach to optimize the hypertension diagnosis and care cascade for PLHIV individuals (SAIA-HTN): a hybrid type III cluster randomized trial 
    Gimbel, Sarah; Mocumbi, Ana O.; Ásbjörnsdótti, Kristjana; Coutinho, Joana; Andela, Leonel; Cebola, Bonifacio; Craine, Heidi; Crocker, Jonny; Hicks, Leecreesha; Holte, Sarah; Hossieke, Rodrigues; Itai, Edgar; Levin, Carol; Manaca, Nelia; Murgorgo, Filipe; Nhumba, Miguel; Pfeiffer, James; Ramiro, Isaias; Ronen, Keshet; Sotoodehnia, Nona; Uetela, Onei; Wagner, Anjuli; Weiner, Bryan J.; Sherr, Kenneth (BMC, 2020)
    Across sub-Saharan Africa, evidence-based clinical guidelines to screen and manage hypertension exist; however, country level application is low due to lack of service readiness, uneven health worker motivation, ...
  • The systems analysis and Improvement approach: specifying core components of an implementation strategy to optimize care cascades in public health 
    Gimbel, Sarah; Ásbjörnsdóttir, Kristjana; Banek, Kristin; Borges, Madeline; Crocker, Jonny; Coutinho, Joana; Cumbe, Vasco; Dinis, Aneth; Eastment, McKenna; Gaitho, Douglas; Lambdin, Barrot H.; Pope, Stephen; Uetela, Onei; Hazim, Carmen; McClelland, R. Scott; Mocumbi, Ana O.; Muanido, Alberto; Nduati, Ruth; Njuguna, Irene N.; Wagenaar, Bradley H.; Wagner, Anjuli; Wanje, George; Sherr, Kenneth (BMC, 2023)
    Background Healthcare systems in low-resource settings need simple, low-cost interventions to improve services and address gaps in care. Though routine data provide opportunities to guide these efforts, frontline providers ...
  • Rationale and design of the Pan AfricanPulmonary hypertension Cohort(PAPUCO) study: implementinga contemporary registry on pulmonaryhypertension in Africa 
    Thienemann, Friedrich; Dzudie, Anastase; Mocumbi, Ana O.; Blauwet, Lori; Sani, Mahmoud U.; Karaye, Kamilu M.; Ogah, Okechukwu S.; Mbanze, Irina; Mbakwem, Amam; Udo, Patience; Tibazarwa, Kemi; Ibrahim, Ahmed S.; Burton, Rosie; Damasceno, Albertino; Stewart, Simon; Sliwa, Karen (BMJ, 2014-09)
    Introduction:Pulmonary hypertension (PH) is adevastating, progressive disease with increasinglydebilitating symptoms and usually shortened overall lifeexpectancy due to a narrowing of the pulmonaryvasculature and consecutive ...
  • Technology and implementation science to forge the future of evidence-based psychotherapies: the PRIDE scale-up study 
    Wainberg, Milton L.; Gouveia, Maria Lídia; Stockton, Melissa Ann; Feliciano, Paulino; Suleman, Antonio; Mootz, Jennifer J.; Mello, Milena; Salem, Andre Fiks; Greene, M. Claire; Bezuidenhout, Charl; Ngwepe, Phuti; Lovero, Kathryn L.; Santos, Palmira Fortunato dos; Schriger, Simone H.; Mandell, David S.; Mulumba, Rogerio; Anube, Anibal Neves; Mabunda, Dirceu; Mandlate, Flavio; Cournos, Francine; Alves-Bradford, Jean-Marie; Nicholson, Terriann; Kann, Bianca; Fumo, Wilza; Duarte, Cristiane S.; Mari, Jair de Jesus; Mello, Marcelo F.; Mocumbi, Ana O.; Oquendo, Maria A.; Weissman, Myrna M. (BMJ, 2020)
    ObjectiveTo report the interim results from the training of providers inevidence-based psychotherapies (EBPs) and use of mobile applications.Design and SettingThe Partnerships in Research to Implement and Disseminate ...
  • Endomyocardial fibrosis: a form ofendemic restrictive cardiomyopath 
    Mocumbi, Ana O. (Global Cardiology Science and Practice, 2012)
    Endomyocardial fibrosis is a form of endemic restrictive cardiomyopathy that affects mainly childrenand adolescents, and is geographically restricted to some poor areas of Africa, Latin America andAsia. It is a condition ...
  • A systematic review of the spectrum of cardiac arrhythmias in Sub-Saharan Africa 
    Yuyun, Matthew F.; Bonny, Aimé; Ng, G. André; Sliwa, Karen; Kengne, Andre Pascal; Chin, Ashley; Mocumbi, Ana O.; Ngantcha, Marcus; Ajijola, Olujimi A.; Bukhman, Gene (Global Heart, 2020)
    Major structural cardiovascular diseases are associated with cardiac arrhythmias, but their full spectrum remains unknown in sub-Saharan Africa (SSA), which we addressed in this systematic review. Atrial fibrillation/atrial ...
  • Acute rheumatic fever and rheumatic heart disease: highlighting the role of group a streptococcus in the global burden of cardiovascular disease 
    Auala, Tangeni; Zavale, Ben’Lauro Goncalves; Mbakwem, Amam Çhinyere; Mocumbi, Ana O. (MDPI, 2022)
    Group A Streptococcus (GAS) causes superficial and invasive infections and immune mediated post-infectious sequalae (including acute rheumatic fever/rheumatic heart disease). Acute rheumatic fever (ARF) and rheumatic ...
  • Recent advances in the epidemiology, diagnosis andtreatment of endomyocardialfibrosis in Africa 
    Mocumbi, Ana O.; Falase, Ayodele O. (BMJ and BCS, 2013-05)
    Endomyocardialfibrosis (EMF) continues to be animportant and disabling disease in many parts of Africa,although its prevalence has declined in some parts ofthe continent. Increased access to medical care ingeneral and ...
  • Cardiovascular effects of indoor air pollution from solid fuel: relevance to Sub-Saharan Africa 
    Mocumbi, Ana O.; Stewart, Simon; Patel, Sam; Al-Delaimy, Wael K. (Springer, 2019)
    Purpose of Review This research aims to summarize evidence on the cardiovascular effects of indoor air pollution (IAP) from solid fuel and identify areas for research and policy for low- and middle-income countries. Recent ...
  • Persisting burden and challenges of rheumaticheart disease 
    Marijon, Eloi; Mocumbi, Ana O.; Narayanan, Kumar; Jouven, Xavier; Celermajer, David S. (European Heart Journal, 2021)
    Rheumatic heart disease (RHD) is the result of episodes of acute rheumatic fever with valvular (and other cardiac) damage caused by anabnormal immune response to group A streptococcal infections, usually during childhood ...
  • Screening for rheumatic heart disease: evaluationof a simplified echocardiography-based approach 
    Mirabel, Mariana; Celermajer, David S.; Ferreira, Beatriz; Tafflet, Muriel; Perier, Marie-Cecile; Karam, Nicole; Mocumbi, Ana-Olga; Jani, Dinesh N.; Sidi, Daniel; Jouven, Xavier; Marijon, Eloi (Oxford University Press, 2012)
    Portable echocardiography has emerged as a potential tool to detect rheumatic heart disease (RHD) early. Complexechocardiographic criteria used in recent epidemiological studies may be difficult to translate into daily ...
  • Forgotten cardiovascular diseases in Africa 
    Sliwa, Karen; Mocumbi, Ana O. (Springer, 2010)
    Much of the global burden of cardiovascular disease is now carried by low and middle income countries. Unfortunately, many of these regions are still grappling with poverty and infection-related cardiovascular diseases, such ...
  • Lack of focus on cardiovascular disease in sub-Saharan Africa 
    Mocumbi, Ana O. (Cardiovascular Diagnosis and Therapy, 2012)
    Research into cardiovascular disease in Sub-Saharan Africa has been hampered by lack of funding and expertise. However, hospital- and community-based data reveal high economic and social costs of these diseases to the ...
  • Secondary antibiotic prophylaxis for latent rheumatic heart disease 
    Beaton, Andrea; Okello, Emmy; Rwebembera, Joselyn; Engelman, Daniel; Alepere, Juliet; Canales, Lesley; Carapetis, Jonathan; DeWyer, Alyssa; Lwab, Peter; Mirabel, Mariana; Mocumbi, Ana O.; Murali, Meghna; Nakitto, Miriam; Ndagire, Emma; Nunes, Maria C.P.; Omara, Isaac O.; Sarnacki, Rachel; Scheel, Amy; Wilson, Nigel; Zimmerman, Meghan; Zühlke, Liesl; Karthikeyan, Ganesan; Sable, Craig A.; Steer, Andrew C.; Grobler, Anneke (Massachusetts Medical Society, 2021)
    Rheumatic heart disease affects more than 40.5 million people worldwide and results in 306,000 deaths annually. Echocardiographic screening detects rheumatic heart disease at an early, latent stage. Whether secondary ...

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