Abstract:
Climate change is a major contributor to annual winter peaks in cardiovascular events across the globe. However, given the paradoxical
observation that cardiovascular seasonality is observed in relatively mild as well as cold climates, global warming may not be as
positive for the syndrome of heart failure (HF) as some predict. In this article, we present our Model of Seasonal Flexibility to explain
the spectrum of individual responses to climatic conditions. We have identified distinctive phenotypes of resilience and vulnerability to
explain why winter peaks in HF occur. Moreover, we identify how better identification of climatic vulnerability and the use of multifaceted
interventions focusing on modifiable bio-behavioural factors may improve HF outcomes.
