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Browsing by Author "Sacarlal, Jahit"

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A 10 year study of the cause of death in children under 15 years in Manhiça, Mozambique

Sacarlal, Jahit; Nhacolo, Ariel Q.; Sigaúque, Betuel; Nhalungo, Delino A.; Abacassamo, Fatima; Sacoor, Charfudin N.; Aide, Pedro; Machevo, Sonia; Nhampossa, Tacilta; Macete, Eusébio V.; Bassat, Quique; David, Catarina; Bardají, Azucena; Letang, Emili; Saúte, Francisco; Aponte, John J.; Thompson, Ricardo; Alonso, Pedro L. (BMC, 2009)

Background: Approximately 46 million of the estimated 60 million deaths that occur in the world each year take place in developing countries. Further, this mortality is highest in Sub-Saharan Africa, although causes of ...
Air pollution and other risk factors might buffer COVID-19 severity in Mozambique

Sumbana, José; Sacarlal, Jahit; Rubino, Salvatore (Pubmed, 2020-07-11)

Mozambique is located on the East Coast of Africa and was one of the last countries affected by COVID-19. The first case was reported on 22 March 2020 and since then the cases have increased gradually as they ...
Altered mental status among febrile hospitalized HIV-Infected children aged 0 - 59 months in Mozambique

Moon, Troy D.; Maússe, Fabião E.; Gebretsadik, Tebeb; Kenga, Darlenne B.; Charles, Pedro; Agy, Mustuafá; Simbine, Samuel; Sacarlal, Jahit (Oxford University Press., 2020)

Background:Altered mental status (AMS) is a priority presenting sign that must be assessed inHIV-infected, febrile children, yet diagnosis is difficult in areas with limited diagnostic capacity.Malaria and bacterial ...
Antimicrobial resistance of Vibrio cholerae O1 serotype Ogawa isolated in Manhiça District Hospital, southern Mozambique

Mandomando, Inácio; Espasa, Mateu; Vallès, Xavier; Sacarlal, Jahit; Sigaúque, Betuel; Ruiz, Joaquim; Alonso, Pedro (Journal of Antimicrobial Chemotherapy, 2007)

Objetivos: Descrever o perfil de suscetibilidade antimicrobiana de Vibrio cholerae sorotipo O1 isolado Ogawa recuperou de pacientes internados na unidade de cólera do Hospital Distrital da Manhiça (MDH), Moçambique. Métodos: ...
A combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS,S malaria vaccine

White, Michael T.; Bejon, Philip; Olotu, Ally; Griffin, Jamie T.; Bojang, Kalifa; Lusingu, John; Salim, Nahya; Abdulla, Salim; Otsyula, Nekoye; Agnandji, Selidji T.; Lell, Bertrand; Asante, Kwaku Poku; Owusu-Agyei, Seth; Mahama, Emmanuel; Agbenyega, Tsiri; Ansong, Daniel; Sacarlal, Jahit; Aponte, John J.; Ghan, Azra C. (BioMed Central, 2014)

Background: The RTS,S malaria vaccine is currently undergoing phase 3 trials. High vaccine-induced antibody titres to the circumsporozoite protein (CSP) antigen have been associated with protection from infection and ...
Coping strategies used by patients after diagnosis disclosure in the transition to palliative care: a cross-sectional study

Schmauch, Natália Ubisse; Rego, Francisca; Castro, Luísa; Sacarlal, Jahit; Rego, Guilhermina (SAGE, 2023)

Objectives: The objectives of this study were to identify the coping strategies used by cancer and non-cancer patients with palliative needs, and to verify if there were differences in the coping strategies adopted between ...
Detecção molecular e genotipagem de Helicobacter Pylori em pacientes dispépticos atendidos no Hospital Central de Maputo

Majaliwa, Nashon Dussin (Universidade Eduardo Mondlane, 2022-07-01)

Background: Helicobacter pylori (H. pylori) is a human pathogenic bacterium responsible for a variety of gastric diseases, including dyspepsia. The global prevalence of its infection is approximately 50%, but can reach 90% ...
Distinct helper t cell type 1 and 2 responses associated with malaria protection and risk in RTS,S/AS01E vaccinees

Moncunil, Gemma; Mpina, Maxmillian; Nhabomba, Augusto J.; Aguilar, Ruth; Ayestaran, Aintzane; Sanz, Héctor; Campo, Joseph J.; Jairoce, Chenjerai; Barrios, Diana; Dong, Yan; Díez-Padrisa, Núria; Fernande, José F.; Abdulla, Salim; Sacarlal, Jahit; Williams, Nana A.; Harezlak, Jaroslaw; Mordmüller, Benjamin; Agnandj, Selidji T.; Aponte, John J.; Daubenberger, Claudia; Valim, Clarissa; Dobaño, Carlota (Oxford University Press, 2017-05)

Fundo. A vacina contra a malária RTS,S/AS01E tem eficácia moderada, inferior em bebés do que em crianças. Esforços atuais para melhorar A eficácia do RTS,S/AS01E beneficiaria da aprendizagem sobre a imunidade induzida ...
Duration of vaccine efficacy against malaria: 5th year of follow-up in children vaccinated with RTS,S/AS02 in Mozambique

Campo, Joseph J.; Sacarlal, Jahit; Aponte, John J.; Aide, Pedro; Nhabomba, Augusto J.; Dobano, Carlota; Alonso, Pedro L. (Elsevier, 2014)

AprimaryconcernfortheRTS,Smalariavaccinecandidateisdurationofprotection.TheongoingPhaseIIItrialreportedevidenceofwaningefficacywithinthefirstyearfollowingvaccination.MultiplePhaseIIbtrialsdemonstratedearlywaningofefficac ...
Estimated burden of serious fungal infections in Mozambique

Sacarlal, Jahit; Denning, David W. (MDPI, 2018-06)

Abstract: Mozambique is a sub-Saharan African country with limited information on the burden of fungal disease. We estimated the burden of serious fungal infections for the general healthy population and for those at ...
Evaluation of the Mozambique Antiretroviral Therapy (MozART) database as an antiretroviral therapy patient surveillance system, 2017-2018

Fataha, Neusa Vanessa Fernandes Abdul; Gaveta, Sandra; Langa, José Carlos; Banze, Auria Ribeiro; Sacarlal, Jahit; Rossetto, Erika Valeska; Baltazar, Cynthia Semá; Kellogg, Timothy Allen (Pan African Medical Journa, 2022-07)

Introduction: Mozambique antiretroviral therapy is a database used to monitor patients receiving antiretroviral treatment (ART). This study's objective was to evaluate the system for the purpose to monitor patients ...
Evaluation of the multidrug-resistant tuberculosis surveillance system in Maputo City, Mozambique in the period 2017-2018

Balate, Dionísia Alfredo; Manhiça, Ivan; Macuacua, Bachir; José, Benedita; Banze, Denise; Langa, José Carlos; Baltazar, Cynthia Semá; Sacarlal, Jahit; Rossetto, Erika Valeska; Khosa, Celso (Pan African Medical Journal, 2022-04)

Introduction: multidrug-resistant tuberculosis (MDR-TB) remains a public health problem worldwide. In Mozambique, cases of MDR-TB have increased annually. In 2018, 1,206 cases were reported, as compared to 943 cases ...
First-line antituberculosis drug concentrations in infants with HIV and a history of recent admission with severe pneumonia

Chabala, Chishala; Jacobs, Tom G.; Moraleda, Cinta; Ndaferankhande, John M.; Mumbiro, Vivian; Passanduca, Alfeu; Namuziya, Natasha; Nalwanga, Damalie; Musiime, Victor; Ballesteros, Alvaro; Domínguez-Rodríguez, Sara; Chitsamatanga, Moses; Cassia, Uneisse; Nduna, Bwendo; Bramugy, Justina; Sacarlal, Jahit; Madrid, Lola; Nathoo, Kusum J.; Colbers, Angela; Burger, David M.; Mulenga, Veronica; Buck, W. Chris; Mujuru, Hilda A.; Brake, Lindsey H. M. te; Rojo, Pablo; Tagarro, Alfredo; Aarnoutse, Rob E. (Oxford University Press, 2023)

Optimal antituberculosis therapy is essential for favorable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared ...
Frequência de factores de risco associados a co-infecção pelo HBV/HIV em doadores de sangue repositores do Hospital Central de Maputo e do Hospital Provincial de Xai-Xai, 2015

Chilengue, Eugénio Augusto; Sacarlal, Jahit (Revista Moçambicana de Ciências de Saude, 2019)

Foi realizado um estudo descritivo transversal com abordagem quantitativa para identificar a frequência dos factores de risco associados a co-infecção pelo vírus de Hepatite B (HBV) e vírus de imunodeficiência Humana (HIV) ...
High rates of non-tuberculous mycobacteria isolationin Mozambican children with presumptive tuberculosis

Lopez-Varela, Elisa; Garcia-Basteir, Alberto L.; Augusto, Orvalho J.; Fraile, Oscar; Bulo, Helder; Ira, Tasmiya; Gondo, Kizito; Ingen, Jakko van; Naniche, Denise; Sacarlal, Jahit; Alonso, Pedro L. (PLOS, 2017)

Non-tuberculous mycobacteria (NTM) can cause disease which can be clinically and radiologically undistinguishable from tuberculosis (TB), posing a diagnostic and therapeutic challenge in high TB settings. We aim to describe ...
High-risk lineages among extended-spectrum β-lactamase-producing Escherichia coli from extraintestinal infections in Maputo Central Hospital, Mozambique

Santona, Antonella; Sumbana, José João; Fiamma, Maura; Deligios, Massimo; Taviani, Elisa; Simbine, Samuel Elija; Zimba, Tomas; Sacarlal, Jahit; Rubino, Salvatore; Paglietti, Bianca (Elsevier, 2022)

Abstract Extended-spectrum β-lactamase (ESBL)-producing extraintestinal pathogenic Escherichia coli (ExPEC), particularly high-risk lineages, are responsible for severe infections and increased mortality and hospital ...
Improvement of fungal disease identification and management: combined health systems and public health approaches

Cole, Donald C.; Govender, Nelesh P.; Chakrabarti, Arunaloke; Sacarlal, Jahit; Denning, David W. (Lancet Infection Disease, 2017)

More than 1·6 million people are estimated to die of fungal diseases each year, and about a billion people have cutaneous fungal infections. Fungal disease diagnosis requires a high level of ...
Induction and decay of functional complement-fixing antibodies by the RTS,S malaria vaccine in children, and a negative impact of malaria exposure

Kurtovic, Liriye; Agius, Paul A.; Feng, Gaoqian; Drew, Damien R.; Ubillos, Itziar; Sacarlal, Jahit; Aponte, John J.; Fowkes, Freya J. I.; Dobaño, Carlota; Beeson, James G. (BMC, 2019)

Background: Leading malaria vaccine, RTS,S, is based on the circumsporozoite protein (CSP) of sporozoites. RTS,S confers partial protection against malaria in children, but efficacy wanes relatively quickly after ...
Knowledge attitude and practice of students of the superior health schools of the Mozambican universities about Covid-19

Dadá, Abdul Habib Mahomed; Dadá, Mahomed Sidique Abdul Cadar; Sallé, Sheila Norberto; Belo, Celso; Mlucasse, Ramires; Rodriguez, Daimary Mendoza; Tivane, Pita Tomas; Dadá, Zulaikhah Mahomed Sidique; Sacarlal, Jahit (PhD Scientific Review, 2022-01)

In China, a viral disease emerged which spread to the remainder of the world at an impressive speed, making it a pandemic that led a majority of countries in the world to declare a state of partial or total emergency ...
Long-term safety and efficacy of the RTS,S/AS02A malaria vaccine in Mozambican children

Sacarlal, Jahit; Aide, Pedro; Aponte, John J.; Renom, Montse; Leach, Amanda; Mandomando, Inácio; Lievens, Marc; Bassat, Quique; Lafuente, Sarah; Macete, Eusébio; Vekemans, Johan; Guinovart, Caterina; Sigaúque, Betuel; Sillman, Marla; Milman, Jessica; Dubois, Marie-Claude; Demoitie, Marie-Ange; Thonnard, Joelle; Menéndez, Clara; Ballou, W. Ripley; Cohen, Joe; Alonso, Pedro L. (The Infectious Diseases Society of America, 2009-08)

Background. We previously reported that the RTS,S/AS02A vaccine had an acceptable safety profi e, was immunogenic, and demonstrated eff cacy against Plasmodium falciparum malaria disease for 21 months. Methods. We conducted ...

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