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Browsing by Author "Abdulla, Salim"

Browsing by Author "Abdulla, Salim"

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  • A combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS,S malaria vaccine 
    White, Michael T.; Bejon, Philip; Olotu, Ally; Griffin, Jamie T.; Bojang, Kalifa; Lusingu, John; Salim, Nahya; Abdulla, Salim; Otsyula, Nekoye; Agnandji, Selidji T.; Lell, Bertrand; Asante, Kwaku Poku; Owusu-Agyei, Seth; Mahama, Emmanuel; Agbenyega, Tsiri; Ansong, Daniel; Sacarlal, Jahit; Aponte, John J.; Ghan, Azra C. (BioMed Central, 2014)
    Background: The RTS,S malaria vaccine is currently undergoing phase 3 trials. High vaccine-induced antibody titres to the circumsporozoite protein (CSP) antigen have been associated with protection from infection and ...
  • Distinct helper t cell type 1 and 2 responses associated with malaria protection and risk in RTS,S/AS01E vaccinees 
    Moncunil, Gemma; Mpina, Maxmillian; Nhabomba, Augusto J.; Aguilar, Ruth; Ayestaran, Aintzane; Sanz, Héctor; Campo, Joseph J.; Jairoce, Chenjerai; Barrios, Diana; Dong, Yan; Díez-Padrisa, Núria; Fernande, José F.; Abdulla, Salim; Sacarlal, Jahit; Williams, Nana A.; Harezlak, Jaroslaw; Mordmüller, Benjamin; Agnandj, Selidji T.; Aponte, John J.; Daubenberger, Claudia; Valim, Clarissa; Dobaño, Carlota (Oxford University Press, 2017-05)
    Fundo. A vacina contra a malária RTS,S/AS01E tem eficácia moderada, inferior em bebés do que em crianças. Esforços atuais para melhorar A eficácia do RTS,S/AS01E beneficiaria da aprendizagem sobre a imunidade induzida ...
  • Intermittent preventive treatment of Malaria in pregnancy with Mefloquine in HIV-Negative women: a multicentre randomized controlled trial 
    González, Raquel; Mombo-Ngoma, Ghyslain; Ouédraogo, Smaı̈la; Kakolwa, Mwaka A.; Abdulla, Salim; Accrombessi, Manfred; Aponte, John J.; Akerey-Diop, Daisy; Basra, Arti; Briand, Valérie; Capan, Meskure; Cot, Michel; Kabanywanyi, Abdunoor M.; Kleine, Christian; Kremsner, Peter G.; Macete, Eusébio; Mackanga, Jean-Rodolphe; Massougbodji, Achille; Mayor, Alfredo; Nhacolo, Arsenio; Pahlava, Golbahar; Ramharter, Michael; Rupérez, María; Sevene, Esperança; Valá, Anifa; Zoleko-Manego, Rella; Menéndez, Clara (PLOS Medicine, 2014-09)
    Background: Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended by WHO to prevent malaria in African pregnant women. The spread of SP parasite resistance has raised ...
  • Mortality, morbidity, and developmental outcomes in infants born to women who received either mefloquine or sulfadoxine- pyrimethamine as intermittent preventive treatment of malaria in pregnancy: a cohort study 
    Rupérez, María; González, Raquel; Mombo-Ngoma, Ghyslain; Kabanywanyi, Abdunoor M.; Sevene, Esperança; Ouédraogo, Smaı̈lao Aberto; Kakolwa, Mwaka A.; Valá, Anifa; Accrombessi, Manfred; Briand, Valérie; Aponte, John J.; Zoleko, Rella Manego; Adegnika, Ayôla A.; Cot, Michel; Kremsner, Peter G.; Massougbodji, Achille; Abdulla, Salim; Ramharter, Michael; Macete, Eusébio; Menéndez, Clara (PLOS Medicine, 2016-02-23)
    Background: Little is known about the effects of intermittent preventive treatment of malaria in pregnancy (IPTp) on the health of sub-Saharan African infants. We have evaluated the safety of IPTp with mefloquine (MQ) ...
  • Multi-country evaluation of safety of dihydroartemisinin/piperaquine post- licensure in african public hospitals with electrocardiograms 
    Kabanywanyi, Abdunoor M.; Baiden, Rita; Ali, Ali M.; Mahende, Muhidin K.; Ogutu, Bernhards R.; Oduro, Abraham; Tinto, Halidou; Gyapong, Margaret; Sie, Ali; Sevene, Esperança; Macete, Eusébio; Owusu-Agyei, Seth; Adjei, Alex; Compaoré, Guillaume; Valea, Innocent; Osei, Isaac; Yawson, Abena; Adjuik, Martin; Akparibo, Raymond; Kakolwa, Mwaka A.; Abdulla, Salim; Binka, Fred (PLOS ONE, 2016)
    The antimalarial drug piperaquine is associated with delayed ventricular depolarization, causing prolonged QT interval (time taken for ventricular de-polarisation and re-polarisa- tion). There is a lack of safety data ...
  • Prospective observational study to evaluate the clinical safety of the fixed-dose artemisinin-based combination Eurartesim® (dihydroartemisinin/ piperaquine), in public health facilities in Burkina Faso, Mozambique, Ghana, and Tanzania 
    Baiden, Rita; Oduro, Abraham; Halidou, Tinto; Gyapong, Margaret; Sie, Ali; Macete, Eusebio; Abdulla, Salim; Owusu-Agyei, Seth; Mulokozi, Abdunoor; Adjei, Alex; Sevene, Esperanca; Compaoré, Guillaume; Valea, Innocent; Osei, Isaac; Yawson, Abena; Adjuik, Martin; Akparibo, Raymond; Ogutu, Bernhards; Upunda, Gabriel Leonard; Smith, Peter; Binka, Fred (BMC, 2015)
    Background: The World Health Organization recommends artemisinin-based combination (ACT) for the treatment of uncomplicated malaria. Post-licensure safety data on newly registered ACT is critical for evaluating their ...
  • Safety of artemether-lumefantrine exposure in first trimester of pregnancy: an observational cohort 
    Mosha, Dominic; Mazuguni, Festo; Mrema, Sigilbert; Sevene, Esperança; Abdulla, Salim; Genton, Blaise (BioMed Central, 2014-03-27)
    Background: There is limited data available regarding safety profile of artemisinins in early pregnancy. They are, therefore, not recommended by WHO as a first-line treatment for malaria in first trimester due to associated ...
  • Safety of artemether-lumefantrine exposure in first trimester of pregnancy: an observational cohort 
    Mosha, Dominic; Mazuguni, Festo; Mrema, Sigilbert; Sevene, Esperanca; Abdulla, Salim; Genton, Blaise (BioMed Central, 2014)
    Background: There is limited data available regarding safety profile of artemisinins in early pregnancy. They are, therefore, not recommended by WHO as a first-line treatment for malaria in first trimester due to ...
  • Young adolescent girls are at high risk for adverse pregnancy outcomes in sub-Saharan Africa: an observational multicountry study 
    Mombo-Ngoma, Ghyslain; Mackanga, Jean-Rodolphe; González, Raquel; Ouédraogo, Smaı̈la; Kakolwa, Mwaka A.; Manego, Rella Zoleko; Basra, Arti; Rupérez, María; Cot, Michel; Kabanywanyi, Abdunoor M.; Matsiegui, Pierre-Blaise; Agnandji, Seldiji T.; Valá, Anifa; Massougbodji, Achille; Abdulla, Salim; Adegnika, Ayôla A.; Sevene, Esperança; Macete, Eusébio; Yazdanbakhsh, Maria; Kremsner, Peter G.; Aponte, John J.; Menéndez, Clara; Ramharter, Michael (BMJ, 2016-04-14)
    Objectives One of Africa's most important challenges is to improve maternal and neonatal health. The identification of groups at highest risk for adverse pregnancy outcomes is important for developing and implementing ...