Cancro do colo do útero numa população de Moçambique - factores de causalidade: factores envolvidos na transformação e progressão neoplásticas: mucinas e carbohidratos associados a mucinas

Abstract

Cervical cancer is the second most common malignancy in women worldwide, and 80% of cases occur in developing countries. It is well documented that high-risk types of the human papilloma virus (HPV) are the casual determining factor, being present in a high percentage of invasive carcinomas and their precursor lesions.Additional factors, such as other infectious diseases, have been described as having a supporting role in cervical cancer. Some authors suggest an association between schistosomiasis and cervical cancer in areas where this parasitic disease is hyper-endemic.On the other hand, the changes resulting from HPV infection and / or schistosomiasis in the glycocylation pattern are not known, namely when it comes to the expression of simple mucin antigens and a mucin-like glycoprotein of the mucin.